Informatics Publishing Limited

Prajakta A. Kokane ¹, Bhushan A. Bhairav ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN

Abstract

Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Benazepril Hydrochloride. It is a angiotensin converting enzyme inhibitors. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Benazepril Hydrochloride in methanol showed maximum wavelength at 237 nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Benazepril Hydrochloride with correlation coefficient 0.961 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.

Keywords

Benazepril Hydrochloride, Methanol, Water, Co-Solvency Method, Spectrophotometer and Validation.

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Nikita S. Malekar ¹, Sheetal B. Gondkar ¹, Bhushan A. Bhairav ¹, Pinak S. Paralkar ², Ravindra B. Saudagar ³

Affiliations
1 Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics , KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, KCT’S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Development of pH sensitive Naratriptan Hydrochloride in-situ nasal gel was aimed to improve absorption. In the present research work mixture of Carbopol-934 and Xanthan Gum were used to benefit pH sensitive gelation property. Different formulation were prepared by different concentrations of Carbopol-934 and Xanthan Gum .In this formulation the release profile depend on the concentration of Carbopol-934 and Xanthan Gum. These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, and drug and excipients compatability. A 3² factorial design was applied to see the effect of various Carbopol-934 (X₁) and Xanthan gum (X₂) on the various models to a certain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The study indicates that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation. The objective of this study was to formulate a intranasal gel for drug targeting directly to brain via olfactory lobe pathway.

Keywords

Anti-Migraine, Carbopol-934, Xanthan Gum, In-Situ Gelling System, pH Sensitive.

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